Introduction: The aliphatic monoterpene 3, 7-dimethyl-2, 6-octadienal (Citral) is a flavour additive widely used in the cosmetic and food industries. It has been shown to have a negative impact on female fertility acting via hormone receptors. No data is available about the effects of Citral on the male reproductive system. Objective: This study was carried out to study the effects of Citral on body weight, weights of the testes, epididymis, seminal vesicles, prostate, liver and kidneys, hepatic enzyme levels, plasma testosterone level and haemoglobin concentration, red blood cell count, white blood cell count and packed cell volume. Materials and Methods: Mature male rats (n = 12) were given Citral at a dose of 300 mg/kg body weight in 1 mL of olive oil, by single intraperitoneal injection for 14 consecutive days. The control group was treated similarly with 1ml of olive oil alone. On day 15, organ weights, plasma testosterone levels, hepatic enzyme levels and haematological parameters were assessed. Results: There were no effects on the liver enzyme levels or on haematological parameters. Testicular and accessory reproductive organ weights and plasma testosterone levels were significantly reduced in the Citral treated group, compared with the controls (P < L.05).Conclusion: Citral in a dose of 300mg/kg body weight in 1 ml of olive oil, by single intraperitoneal injection for 14 consecutive days in rats leads to reduction in weights of the testes, epididymis, seminal vesicles, prostate and plasma testosterone levels.
How to Cite:
Ilayperuma, I., (2009). Effects of intraperitoneal administration of Citral on male reproductive organs in the rat. Galle Medical Journal. 13(1), pp.29–32. DOI: http://doi.org/10.4038/gmj.v13i1.891