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Seroconversion following Hepatitis B immunization in National Immunization Programme in a selected Medical Officer of Health area in Galle District

Authors:

W. M. D. G. B. Wijayaratne ,

University of Ruhuna, Galle, LK
About W. M. D. G. B.
Department of Microbiology, Faculty of Medicine
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H. A. Ubeysekara,

Provincial Director of Health Services Office, Southern Province, LK
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N. De Silva,

University of Ruhuna, Galle, LK
About N.
Department of Microbiology, Faculty of Medicine
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G. Galagoda

Medical Research Institute, Colombo, LK
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Abstract

Introduction: Hepatitis B immunization was introduced into the National Immunization Programme (NIP) of Sri Lanka in three phases in 2003. The study evaluates the protective efficacy of 2, 4, 6 month schedule of hepatitis B vaccination in the NIP in Sri Lanka.

 

Methods: A cross sectional study carried out among 154 infants (completed 9 months of age) attending the NIP in the Bope Poddala Medical Officer of Health (MOH) area in Galle District in 2008. Hepatitis B surface antibody (HBsAb) titres were tested using a quantitative enzyme immunoassay test. Forty-two infants detected with low titres of antibodies were given a booster dose of hepatitis B vaccine and HBsAb titer was retested 2 - 4 weeks later.

 

Results: The overall protection (HBsAb titre >10 mIU/mL) after 3 doses of vaccine was 94.2% with a geometric mean titre of 233.37 mIU/mL. There were 5.8% infants with HBsAb titres <10 mIU/mL and 30.5% with HBsAb titres between 10 to 100 mIU/mL. Sex, birth weight, body mass index and weight for height were not significantly associated with HBsAb levels. None of the infants had potential risk factors for acquiring hepatitis B virus infection. Only 26 out of 42 revaccinated infants returned for repeat testing of antibody levels where all had demonstrated a protective level.

 

Conclusions: The majority of infants seroconverted following three doses of Hepatitis B vaccine in NIP in Sri Lanka and the rest picked up the antibody levels following a booster dose.
How to Cite: Wijayaratne, W.M.D.G.B., Ubeysekara, H.A., De Silva, N. and Galagoda, G., 2019. Seroconversion following Hepatitis B immunization in National Immunization Programme in a selected Medical Officer of Health area in Galle District. Galle Medical Journal, 24(1), pp.1–7. DOI: http://doi.org/10.4038/gmj.v24i1.8000
Published on 30 Mar 2019.
Peer Reviewed

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