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Community screening for undiagnosed dysglycaemia in a semi-urban locality in Sri Lanka

Authors:

A. T. I. M. Amarasinghe ,

University of Ruhuna, Galle, LK
About A. T. I. M.
Department of Pharmacology
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S. Lekamwasam,

University of Ruhuna, Galle, LK
About S.
Department of Medicine, Faculty of Medicine
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T. P. Weerarathna,

University of Ruhuna, Galle, LK
About T. P.
Department of Medicine, Faculty of Medicine
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M. Sumanatilleke

National Hospital of Sri Lanka, Colombo, LK
About M.
Endocrinology Unit
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Abstract

Introduction: Previous studies on the prevalence of pre-diabetes and diabetes in Sri Lanka have shown conflicting results. We studied the prevalence of pre-diabetes and diabetes using fasting plasma glucose (FPG) and 75g oral glucose tolerance (OGTT) test among a representative sample of adults in a semi-urban locality in Southern Sri Lanka. Sensitivity and specificity of FPG over OGTT in diagnosing pre-diabetes and diabetes were calculated.

 

Methods: Healthy adults, aged 20-75 years, selected by multi-stage random sampling from one medical officer of health area in Southern Sri Lanka were screened with FPG and 75g OGTT. Subjects known to have diabetes were excluded.

 

Results: Mean (SD) age of men (n=234) and women (n=593) were 44 (10.1) and 43(10.8) years, respectively. With OGTT, 157 (19.0%) subjects had impaired glucose tolerance while another 60(7.3%) had diabetes. WithFPG, 270 (32.6%) had impaired fasting glycaemia while another 51(6.2%) had diabetes. Prevalence of prediabetes or diabetes was not different among men and women by OGTT; 55 (23.5%) vs 162 (27.3%), p=0.293while it was significantly different by FPG; 107 (45.7%) vs 214 (36.1%), p=0.011. Prevalence of pre-diabetes or diabetes was significantly higher in age group ≥45 yrs compared to age <45 yrs by both tests. FPG showed low sensitivity (44.7%) but higher (76.1%) specificity of detecting dysglycaemia. FPG showed sensitivity of 53.3% and specificity of 97.5% in detecting undetected diabetes.

 

Conclusions: Prevalence of pre-diabetes is higher than in previous studies in Sri Lanka. Significantly higher proportion of males compared to females, had pre-diabetes or diabetes by FPG test. Compared to subjects age <45 years, the prevalence of pre-diabetes or diabetes was significantly higher among those ≥45 years. FPG lacks adequate sensitivity and specificity to detect those with diabetes or dysglycaemia.
How to Cite: Amarasinghe, A.T.I.M., Lekamwasam, S., Weerarathna, T.P. and Sumanatilleke, M., 2020. Community screening for undiagnosed dysglycaemia in a semi-urban locality in Sri Lanka. Galle Medical Journal, 25(3), pp.91–97. DOI: http://doi.org/10.4038/gmj.v25i3.8038
Published on 02 Nov 2020.
Peer Reviewed

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