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Interaction between lean, fat and bone masses among patients with chronic kidney disease; a cross-sectional comparative study

Authors:

E. H. Silva ,

University of Ruhuna, Galle, LK
About E. H.
Department of Medical Laboratory Science, Faculty of Allied Health Sciences
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C. M. Wickramatilake,

University of Ruhuna, Galle, LK
About C. M.
Department of Biochemistry, Faculty of Medicine
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S. Lekamwasam,

University of Ruhuna, Galle, LK
About S.
Department of Medicine, Faculty of Medicine
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L. K. B. Mudduwa,

University of Ruhuna, Galle, LK
About L. K. B.
Department of Pathology, Faculty of Medicine
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R. A. Ubayasiri

Teaching Hospital Karapitiya, Galle, LK
About R. A.
Department of Vascular and Transplant Surgery
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Abstract

Introduction: Interactions between three major body compartments; lean, fat and bone masses are essential for the maintenance of optimum bodily functions. This interaction is disturbed by factors such as advancing age, disease and drugs. The aim of the study was to understand the interaction of body compartments in chronic kidney disease (CKD) to optimise disease outcome.

 

Methods: Fifty patients (38 males) with CKD awaiting kidney transplant at Teaching Hospitals, Karapitiya and Kandy and 50 age and gender matched control subjects were compared. Socio-demographic data, social habits and anthropometric measurements with blood pressure was obtained. Both patients and controls underwent DEXA scan to assess body composition.

 

Results: Mean (SD) age of the patients was 48(9.6) years. In both groups; patients with CKD and participants in the control group, total body lean mass (TBLM) showed significant correlations with total body bone mineral density (TBBMD) (patients: r = 0.38, p = 0.008) (controls: r = 0.57, p = <0.001) and total body bone mineral content (TBBMC) (patients: r = 0.62, p = <0.001) (controls: r = 0.78, p = <0.001). No significant correlations were observed between total body fat mass (TBFM) and TBBMD or TBBMC. When regression models were fitted with TBBMD and TBBMC as dependent variables and TBLM as the independent variable, 1kg difference in TBLM was associated with 0.007 g/cm2 (p = 0.02) and 0.010 g/cm2 (p = 0.012) change in TBBMD in patients and controls, respectively. Furthermore, 1kg difference in TBLM was associated with 32 g (p = 0.02) and 33 g (p = 0.018) difference in TBBMC in patients with CKD and participants in the control group, respectively.

 

Conclusions: Similar to participants in the control group, TBLM is a better predictor of TBBMC and TBBMD compared to TBFM and TRFM in patients with end stage renal disease (ESRD) and this knowledge can be used in health promotion programs to improve bone health of these patients.
How to Cite: Silva, E.H., Wickramatilake, C.M., Lekamwasam, S., Mudduwa, L.K.B. and Ubayasiri, R.A., 2021. Interaction between lean, fat and bone masses among patients with chronic kidney disease; a cross-sectional comparative study. Galle Medical Journal, 26(3), pp.99–104. DOI: http://doi.org/10.4038/gmj.v26i3.8100
Published on 15 Sep 2021.
Peer Reviewed

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